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(1992) used in situ hybridization to map the ITPKA gene to 15q14-q21. REFERENCES Erneux, C., Roeckel, N., Takazawa, K., Mailleux, P., Vassart, G., Mattei, M. G. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. Functional Associations. ITPKA has 3,320 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 82 datasets.

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The ITPKC gene provides instructions for making one version (isoform) of the inositol 1,4,5-trisphosphate 3-kinase (ITPK) enzyme. This enzyme helps add a cluster of oxygen and phosphorus atoms (a phosphate group) to a molecule called Ins(1,4,5)P3 to produce a molecule called Ins(1,3,4,5)P4. Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases… Expand ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers. Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF. J Thorac Oncol.

Under physiological conditions, ITPKA is only identified in neurons and testis [ 6 ]. Plasmid pCNL-N1_ITPKA from Dr. Yasushi Okada's lab contains the insert inositol triphosphate 3-kinase A and is published in Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112.

SCAN-B MutationExplorer

The activity of the inositol Plasmid pCNL-N1_ITPKA from Dr. Yasushi Okada's lab contains the insert inositol triphosphate 3-kinase A and is published in Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112. Epub 2015 Mar 23.

SCAN-B MutationExplorer

Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF The C-terminal part of ITPKB, namely residues 187 to 462, was 68% identical to ITPKA in amino acid sequence.

Itpka gene

HSA: 3706(ITPKA) 100988859(ITPKA). GGO: 101142571(ITPKB) 115930848(ITPKA). PON CSAB: 103229987(ITPKB) 103245796(ITPKA). RRO   Use the search box at the top right of all Ensembl views to search for a gene, phenotype, sequence Gene-based displays Gene: ITPKA ENSG00000137825.
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Cited in 1 publications. proteins (a major isoform for each protein encoding gene). Create a map of tibodies. Number of genes/antibodies included per new release ITPKA (lat. vent). 2, Gene expression cluster, Dusp1-/- * LPS vs.

Function i Catalytic activity i. 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5 2016-09-01 2006-05-11 General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. ITPKA. Gene … ITPKA Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, ITPKA Genome Browser, ITPKA References.
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2021-03-02 ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and Metabolism . Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity . ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis. ITPKA gene body methylation regulates its expression and thus serves as a novel and potential biomarker for early cancer detection.

The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Summary of ITPKA expression in human tissue. Distinct expression in astrocytes and processes in CNS. The product SIRGT96128WQ-2OMe is a type of small interfering RNA (siRNA) that targets Itpka gene and regulates the expression of gene.
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Instructions A 1 Additional file 1 - Genes differentially regulated by

Brief description, Adrenergic Pathway. Full description or abstract. Collection, C2: curated gene  Wnt/Ca2+/cyclic GMP signaling. Full description or abstract. Collection, ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks C2_CP:  8 Jan 2014 Recently, genome-wide association studies have identified allelic variants (A) Immunoblot analysis for ITPKB and ITPKA expression in frontal  itpka, itpkb, itpkc, insp3 3-kinase, ip3k, ip3k-a, ip3kb, insp3kinase, ins(1,4,5)p3 kinase, inositol 1,4,5-trisphosphate 3-kinase c, more. top print hide 112 entries  5 May 2014 The single human member is called ITPK1, but should not be confused with the human genes ITPKA, ITPKB and ITPKC, which belong to the  Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene. ITK is  This 12-sample array allows analysis of genetic and structural variation in the human genome, such as duplications, deletions, amplifications, copy-neutral LOH,  Learn about mechanism of action for PIQRAY.

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IP3KA siRNA h, shRNA and Lentiviral Particle Gene Silencers

ITPKA - Inositol-trisphosphate 3-kinase A - Homo sapiens (Human) - ITPKA gene & protein UniProtKB - P23677 (IP3KA_HUMAN) ITPKA (inositol-trisphosphate 3-kinase A) ITPKA DrugBank Gene Name P23677 UniProt Accession 3706 Entrez Gene Id Gene Info: Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Itpka - Inositol-trisphosphate 3-kinase A - Rattus norvegicus (Rat) - Itpka gene & protein UniProtKB - P17105 (IP3KA_RAT) Itpka Gene Detail Summary Symbol. Itpka Name. inositol 1,4,5-trisphosphate 3-kinase A. Synonyms. IP3-kinase A, MGC:28924 Feature Type. protein coding gene. IDs. MGI Inositol-triphosphate 3-kinase A gene (ITPKA) gene body methylation serves as a potential diagnostic biomarker for early cancer detection.